For the treatment of Sepsis, MediSieve plans to use a combination of different magnetic particles to target both the pathogens that are the root cause of the disease and the cytokines that drive the immune response.
Sepsis is caused by pathogens from an infection which circulate in a patient’s bloodstream. These can elicit a dysregulated immune response that can escalate to multiple organ failure and death. The challenge in Sepsis is that both the pathogens (typically bacteria) and the body’s own response contribute to the disease. The destruction of bacteria by the immune system or antibiotics creates large quantities of endotoxins, which aggravate the immune response and can escalate Sepsis even while treatment is being given.